Aseptic BFS filling technology has been widely used in the global pharmaceutical industry. However, with the increasing use of BFS equipment, a series of problems such as poor management of some equipment, low operating efficiency, and failure to reach planned capacity have arisen. How to improve the operation efficiency of BFS equipment is very important.
In recent years, the pharmaceutical industry has
encountered new opportunities and challenges as more new drugs and new
pharmaceutical technologies have emerged. As well as pharmaceutical machinery
manufacturers are dedicating to provide new and more flexible solutions. But
pharmaceutical manufacturing processes have historically lagged behind in
efficiency compared with those of other consumer products industries. With the
stricter requirements from regulatory agencies, the cost of bringing new drugs
to market is increasing, pharmaceutical companies have to take a closer look at their manufacturing
processes to make them more efficient, and to stay competitive.
Aseptic BFS filling technology has been
widely used in the global pharmaceutical industry. However, with the increasing
use of BFS equipment, a series of problems such as poor management of some
equipment, low operating efficiency, and failure to reach planned capacity have
arisen. How to improve the operation efficiency of BFS equipment is very
important. It should ensure the normal operation
time of the equipment to the greatest extent, the equipment is working in a
high-performance state and the product
qualification rate to the greatest extent.
1.BFS Processing of Aseptic Pharmaceutical Liquids
BFS technology focus on uptime and changeover time
improvement, aseptic BFS machines present highly efficient systems for
production of sterile liquid products.
BFS is a self-contained process. It streamlines efficiency
for the entire liquid filling and packaging production process with the
consolidation of process steps.
BFS technology integrates a three-step process of blow molding, sterile filling, and hermetic sealing in a continuous, highly-automated operation. The capability for rapid container closure and minimized aseptic interventions is the unique advantage for aseptic BFS systems compared with conventional aseptic processing. Furthermore, the use of recyclable plastic resins. low-density polyethylene, high-density polyethylene and polypropylene the BFS process to produce aseptic containers for injectables, ophthalmics, biologicals, and vaccines are generally considered inert by FDA.
2. Simplified BFS Machine Design Improves Uptime
In pharmaceutical processing, the filling process
determines line speed.Such as the manually dependent processes can cuase the system
delays and downtime in aseptic packaging,which can bring significant throughput
and cost consequences.
Conversely, automation plays important role in the aseptic
process on improving uptime. The most advanced aseptic BFS systems are quite
automated, compared with conventional aseptic processing. These BFS machines
are designed to require minimum human access while operating under a controlled
environment. Various in-process control parameters utilizing the latest
generation of fully system integrated PLCs control and monitor container
weight, fill weight, wall thickness, isolation of visual defects, and other
factors, facilitating optimized system function.
The forming, filling, and sealing steps in BFS machines are
achieved in one-unit operation—the cycle being completed within seconds. Such
automation eliminates unneeded manpower and reduces the risk to product
integrity. These BFS machines shorten machine cycle time and minimize the time
required to perform complex tasks and increase efficiency in process
operations. The automated process technologies improve product quality and
consistency as well as increase production throughput.
3. Guarantee the Uptime of Equipment
Maintaining uptime is a key factor to reaching high levels
of efficiency in pharmaceutical manufacturin, which has always been of critical
importance to manufacturers in every industry. When throughput is interrupted,
or not running because of downtime or changeovers, the entire process line is
affected, which can present a significant production loss to the pharmaceutical
manufacturer.
Advanced BFS machines can approach 99% uptime efficiency, significantly higher than conventional aseptic processing, which is plagued with slow-downs, in part because of manual interventions. BFS also performs noticeably higher than the peak 70% operating efficiency of the world’s most streamlined pharmaceutical manufacturing facilities.
One of the most costly and time-consuming activities within pharmaceutical manufacturing is changeovers of packaging equipment Indeed, the most critical packaging machine feature is the changeover adaptability .To change the packaging equipment impact production time greatly.The versatility of packaging equipment to facilitate rapid changeovers plays very important role in pharmaceutical manufacturing, and aseptic BFS systems exemplify this initiative.
Many BFS machines are configured to produce more than one
bottle shape or format, which is easy to change over from one container size to
another. A BFS machine can be designed to produce a series of 2ml, 3ml and 5ml
containers, then switch to a series of 5ml, 10ml and 15ml containers, or to one
of 10ml, 15ml, and 20ml containers, moving from one to the other with relative
ease of machine set-up. This is ideal for manufacturers with the need of changeover
flexibility , such as those performing contract packaging of aseptic liquid
pharmaceutical solutions, BFS systems from Tofflon are capable of producing
containers ranging in size from 0.1 ml to 1000 ml,the production rates from 1200 to 17,000 units per hour, depending
on container configuration.
|
Improved uptime, minimized changeover time and efficient
performance are key factors that have influenced the acceptance of aseptic BFS.
These are critical functions for achieving improved product quality and
profitability in the packaging of aseptic pharmaceutical liquids.